On Monday, the FDA authorized the Pfizer-BioNTech Covid-19 vaccine for children aged 12 to 15 years, and the CDC’s Advisory Committee for Immunization Practices is set to vote on its use in this age group on Wednesday. This comes at a time when the pandemic is raging outside our borders, and it’s already prompted debate over the ethics of vaccinating children in the United States when so many adults in Asia, Latin America, and Africa remain unvaccinated. This is a false equivalence and an unproductive conversation, unlikely to help either adults or children.
Yes, it is true that children rarely die from Covid-19 (although some do). Yes, it is true that most children are not hospitalized with Covid-19 (although many are, particularly those who are immunocompromised or with other underlying conditions). Older children transmit SARS-CoV-2 at rates similar to adults, and new data this week show children accounting for 24 percent of all new infections in the US (up from around 2 percent in April 2020), likely due to the success of our vaccination program in adults. A big unknown is whether children will suffer from long-term consequences (termed post-acute sequelae) of infection, given the typically mild symptoms in the acute phase. We do know that a small minority develop a condition called multisystem inflammatory syndrome in children (MIS-C), which can be life-threatening. As with any Covid-related topic, however, it is about more than just rates of infections and death. The mental health impact on children and adolescents is well documented, as are their learning losses and the exit of women with children from the workforce. These are big problems that we have not yet even begun to address.
As a working parent of three healthy children (one vaccinated, one newly eligible, and one not yet eligible) with a comfortable income, good internet access, and local schools that are following science-based Covid-19 protocols, it is certainly tempting to think that my 15-year-old’s vaccine doses would be better off elsewhere. But is that actually a useful question? As a starting point, for example, the Pfizer-BioNTech vaccine is not currently approved for use in India, although this may certainly change. We know that India needs oxygen, PPE, and other medical supplies, and there are many ways Americans can and should donate to this effort. The Lancet Covid-19 Commission India Task Force calls for a series of actions to contain infections, including, among other steps, a vaccination campaign of 5 million doses per day targeting those over 45 years of age. They estimate that current production in India could meet half of that goal, with significantly increased capacity possible if the financial resources and raw materials are made available. This effort is likely to lead to much greater long-term benefit for India than the less than four days’ worth of Pfizer-BioNTech vaccines (at 5 million doses per day) that would be contributed if all 17 million 12- to 15-year-olds in the US forgo immunization.
The Biden administration published a fact sheet outlining emergency Covid-19 assistance for India on April 28, which outlines $100 million in aid, including manufacturing supplies for AstraZeneca vaccines. Further, the US still holds a stockpile of AstraZeneca vaccines, unlikely to ever be approved here, and these should be directed to countries that can use them now rather than left sitting on a shelf. Many have criticized the administration’s response as inadequate, particularly with regard to intellectual property considerations for Covid-19 vaccines. These are crucial discussions that should be at the forefront of the news reporting. The hypothetical ethical deliberations on Twitter and quotes in the news from some public health talking heads regarding the vaccines for children are a distraction. Of course children should be vaccinated. And of course the US should facilitate global access to vaccines.
As a pediatric HIV specialist, I have seen children again and again placed at the end of the line when it comes to approval of life-saving HIV medicines. In fact, arguably the largest recent advance in the pediatric HIV field came when a brave physician in Mississippi opted to take a non-guideline-driven approach to care for a newborn, desperate to try to prevent HIV transmission. The case of the “Mississippi baby” led to numerous clinical trials and sparked new avenues of research into an HIV cure in children.
The traditionally slow pace of pediatric studies has also been true for Covid-19 vaccines. This is a fundamental problem with the way clinical trials involving children are implemented, and sadly, even the current pandemic was not enough to change it. Further, over 3,000 children die every day of pneumonia and diarrhea globally, and the majority of these deaths are preventable through vaccination. Yet I do not hear urgent calls for US vaccine programs to send our supplies of pneumococcal and rotavirus vaccines overseas. Are children’s lives less important than adults?
Children need to be in school and be able to socialize, and, let’s face it, they will not get back to normal (or even a “new normal”) without vaccines. The skills children and adolescents do or don’t acquire now determine how they will contribute to our future society. Let us do everything in our power to turn the tide of Covid-19’s infections and deaths. But please let us also not frame the discussion as US kids versus Indian adults. That is not fair to children and parents who have been waiting patiently for their turn in the vaccine line and are eager to contribute to community immunity. I get that many public health and medical experts want to raise the temperature on the US government’s response to the pandemic outside our borders. But scapegoating kids in the process is childish.
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